Kefah Mokbel, Professor of Medicine (Honorary) at Cardiff University School of Medicine, shared a post on LinkedIn:
“Do We Still Need Axillary Dissection for Low-Volume Nodal Disease After NACT? AXSANA Says No
The findings the international multicentre AXSANA cohort study (Kühn et al., BJS 2025) shows that completion axillary lymph node dissection (cALND) after neoadjuvant chemotherapy in patients with isolated tumour cells or micrometastases provides no added clinical value—despite frequent nodal upstaging, it did not alter systemic treatment decisions.
These findings strongly suggest that cALND should not be performed for diagnostic purposes alone in this setting.”
Title: Axillary dissection for low-volume nodal involvement after neoadjuvant therapy in breast cancer: multicentre AXSANA cohort study
Authors: Thorsten Kühn, Maggie Banys-Paluchowski, Nina Ditsch, Elmar Stickeler, Michael Hauptmann, Jennifer Schroth, Guldeniz Karadeniz Cakmak, Markus Hahn, Marc Thill, Toralf Reimer, Sarah Fröhlich, Esther Schmidt, Kristina Wihlfahrt, Tomasz Berger, Timo Basali, Franziska Ruf, Angelika Rief, Michael Patrick Lux, Hans-Christian Kolberg, Isabel Teresa Rubio, Maria Luisa Gasparri, Michalis Kontos, Eduard-Alexandru Bonci, Laura Niinikoski, Dawid Murawa, David Pinto, Florentia Peintinger, Ellen Schlichting, Helidon Nina, Hagigat Valiyeva Qanimat, Marian Vanhoeij, Lia Pamela Rebaza, Bilge Aktas Sezen, Katharina Jursik, Geeta Kadayaprath, Lukas Dostalek, Ashutosh Kothari, Andraz Perhavec, Tsvetomir Ivanov, Douglas Zippel, Sarun Thongvitokomarn, Meryem Gunay Gurleyik, Dirk Watermann, Mauro Porpiglia, Annette Lebeau, Rosa Di Micco, Oreste Davide Gentilini, Jana de Boniface, Steffi Hartmann
Read the Full Article on British Journal of Surgery
He also added:
“Our recent editorial published last week is totally aligned with the important findings of the AXSANA cohort study.”
Title: Axillary management in patients with sentinel lymph node micrometastases following neoadjuvant systemic therapy: a call for de-escalation
Authors: Muharrem Oner, Kefah Mokbel
Read the Full Article on Translational Breast Cancer Research
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