Jad Chahoud, Medical Director of IPOP at Moffitt Cancer Center, shared on LinkedIn about a recent paper by Bing-Jian Feng et al. published on JITC:
“New Publication Alert – Journal for ImmunoTherapy of Cancer (JITC)
Thrilled to share a huge team effort exploring the germline genetics of urinary tract cancers (UTCs) and their impact on immune checkpoint inhibitor (ICI) response.
Key findings:
- Through whole-exome sequencing of 810 UTC patients, we identified FOXP3-related germline variants in ~16% of patients.
- These variants confer susceptibility to UTC and interact with DNA mismatch repair pathways.
- Patients carrying these variants had decreased tumor FOXP3 expression, a colder tumor microenvironment, and significantly worse outcomes following ICI.
Our results highlight germline-tumor interactions as an underappreciated factor in both cancer susceptibility and immunotherapy resistance.
Read the full article here below.”
Title: Germline whole-exome sequencing reveals FOXP3-related gene variants conferring urinary cancer susceptibility and associated with immune escape
Authors: Bing-Jian Feng, Wendy Kohlmann, David A Nix, Aaron Atkinson, Kenneth M Boucher, Courtney Carroll, Chris J Stubben, Jill Kolesar, Eric A Singer, Gregory Riedlinger, Stephen Edge, Kamal Kant Sahu, Michelle Churchman, Laura Graham, Bodour Salhia, Alejandro Sanchez, Yousef Zakharia, Bryan P Schneider, Rohit Jain, Lindsey Byrne, Christopher A Moskaluk, Kenneth Nepple, Ahmad Shabsigh, Jad Chahoud, Bradley R Cairns, Sumati Gupta
Other insights from Jad Chahoud.