Bhoor Singh Bhati, Medical Oncologist at AIIMS, New Delhi, shared a post on X:
“Cancer Risk in Inborn Errors of Immunity ≈ 40× Higher than General Population!
Cancer frequency in IEI: 12% (≈40× higher than general population, 0.29%)
Most common subtype (absolute cases): CVID – 1,284 cases
Highest relative risk:
Nijmegen Breakage Syndrome (NBS1) – 50.5% cancer incidence
ATM deficiency – high risk, poor outcomes
Fanconi anemia – strongly linked to cancer
X-linked lymphoproliferative (XLP) syndrome – high cancer burden
Cancer Types
Hematologic malignancies (65.7%)
Most frequent: Diffuse Large B-cell Lymphoma (DLBCL)
Solid tumors:
Digestive tract (stomach, colorectum, liver) most common
Cure rate: lower vs general population
ATM deficiency fatality: 72%
Overall prognosis: poor compared to non-IEI cancers.
Systematic Review and Meta-Analysis. J Clin Immunol 45, 34 (2025).”
Title: Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-Analysis
Journal: Journal of Clinical Immunology
Authors: Saba Fekrvand, Hassan Abolhassani, Zahra Hamidi Esfahani, Najmeh Nameh Goshay Fard, Mahboube Amiri, Helia Salehi, Amir Almasi-Hashiani, Ali Saeedi-Boroujeni, Nazanin Fathi, Maryam Mohtashami, Azadehsadat Razavi, Arash Heidari, Gholamreza Azizi, Shaghayegh Khanmohammadi, Milad Ahangarzadeh, Kiarash Saleki, Gholamreza Hassanpour, Nima Rezaei, Reza Yazdani
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