Triparna Sen, Associate Professor at Icahn School of Medicine at Mount Sinai, shared a post on X about a paper she co-authored with colleagues published in STAR Protocols:

“New Publication Alert!

The Sen Lab has published a new protocol in STAR Protocols. It provides a critical tool for studying immune responses in small-cell lung cancer (SCLC), a cancer known for its resistance to immunotherapy.

We show that this step-by-step method enables researchers to:

Co-culture HLA-matched CD8+ T cells with SCLC cells
Measure T cell activation and tumor cell killing
Quantify cytokine responses to lurbinectedin treatment

This protocol offers a powerful platform to study and enhance anti-tumor immunity in SCLC.

Special thanks to our collaborators and funders for supporting this impactful work.”

“Protocol to co-culture SCLC cells with human CD8+ T cells to measure tumor cell killing and T cell activation”

Authors: Subhamoy Chakraborty, Subhasree Sridhar, Kedwin Ventura, Ramja Sritharan, Anna Tocheva, Triparna Sen.

Triparna Sen: Protocol on co-culturing SCLC cells with CD8+ T cells to study anti-tumor immunity