Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
BM mononuclear cells from myeloma pts release high levels Glutamate which correlates with elevated bone resorption by stimulating osteoclast differentiation via the activation of NF-κB-NFATc1 pathway in low-Glu BM samples.”
Title: High glutamate levels in the bone marrow of multiple myeloma patients promote osteoclast formation: a novel target for osteolytic bone disease
Authors: Denise Toscani, Oxana Lungu, Martina Chiu, Chiara Maccari, Vincenzo Raimondi, Giuseppe Taurino, Massimiliano G. Bianchi, Matteo Scita, Benedetta Dalla Palma, Nicolas Thomas Iannozzi, Rosanna Vescovini, Mattia Dessena, Camilla Sitzia, Paola Storti, Roberta Andreoli, Ovidio Bussolati, Nicola Giuliani
You can read the Full Article in Leukemia.
You can find more posts featuring Robert Orlowski on OncoDaily.
