Joanna Bogusławska, Head of Translational Medicine Doctoral School and Head of the Laboratory of Functional Microbiota Research at Centre of Postgraduate Medical Education, shared a post on LinkedIn about a paper she co-authored with colleagues published in Genes:
“Can plant-based microRNAs help fight cancer?
We just published a study showing that miR395e from cassava (Manihot esculenta) can decrease PD-L1 expression in renal cancer cells. Since PD-L1 helps cancer cells evade the immune system, this discovery could open new possibilities for plant-derived adjuvant therapies in oncology.
Key findings:
- miR395e reduces PD-L1 levels at both mRNA and protein levels.
- Highlights the potential of dietary microRNAs in regulating human gene expression.
- A step towards natural, RNA-based cancer therapies.
Could dietary plant miRNAs be the future of cancer therapy? Let’s discuss!”
“miR395e from Manihot esculenta Decreases Expression of PD-L1 in Renal Cancer: A Preliminary Study”
Authors: Joanna Bogusławska, Aizhan Rakhmetullina, Małgorzata Grzanka, Alex Białas, Beata Rybicka, Joanna Życka-Krzesińska, Tomasz Molcan, Piotr Zielenkiewicz, Leszek Pączek and Agnieszka Piekiełko-Witkowska.
