Gustavo Viani: Higher radiation in Pediatric Ependymomas – more harm than good?

Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, shared a post on X about a paper by Melanie Rose et al. published in the International Journal of Radiation Oncology, Biology, Physics:

“Higher Radiation in Pediatric Ependymomas: More Harm Than Good?

Objective

• Assess optimal radiation dose (≤54 Gy vs. >54 Gy) for pediatric intracranial ependymomas
• Evaluate Local Control (LC), Event-Free Survival (EFS), Overall Survival (OS), and toxicity

Methods

• Meta-analysis of 7 studies (1321 patients)
• Outcomes: LC, EFS, OS, and late toxicities (necrosis, vasculopathy, cognitive lower)

Results

• No survival benefit for >54 Gy.
• Higher doses = more cognitive toxicity

Conclusion

• ≤54 Gy is effective and may reduce toxicity.
• Future research needed on molecular subtypes and STR.”

“Systematic Review and Meta-Analysis of Adjuvant Radiation Dose for Pediatric Patients (≤22 years) with Nonmetastatic Intracranial Ependymomas”

Authors: Melanie Rose et al.

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