E. John Wherry

E. John Wherry: What’s the Difference Between Trm and Exhausted CD8 T cells?

E. John Wherry, Director at Institute for Immunology and Immune Health, shared a post on X he and colleagues co-authored published in bioRxiv.

“What’s the difference between Trm and exhausted CD8 T cells?

Simone Park’s new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses.”

Title: Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

Authors: Simone L. Park, Mark M. Painter, Sasikanth Manne, Victor Alcalde, Maura McLaughlin, Matthew A. Sullivan, Divij Mathew, Leonel Torres, Yinghui J. Huang, David B. Reeg, Naomi R. Douek, Trenton Campos, Max Klapholz, Maria A. Cardenas, Victoria Fang, Shin Foong Ngiow, KC Wumesh, Rishi R. Goel, Amy E. Baxter, Jennifer E. Wu, Melody Tan, Corbett T. Berry, Christoph T. Ellebrecht, Alexander C. Huang, Emily Papazian, Ying Liu, Karthik Rajasekaran, Robert M. Brody, Erica R. Thaler, Devraj Basu, Ahmed Diab, Josephine R. Giles, E. John Wherry

Read The Full Article at bioRxiv.

E. John Wherry: What's the Difference Between Trm and Exhausted CD8 T cells?

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Ahmed Diab Alexander C. Huang Amy E. Baxter cancer Christoph T. Ellebrecht Corbett T. Berry David B. Reeg Devraj Basu Divij Mathew E John Wherry Emily Papazian Erica R. Thaler Jennifer E. Wu Josephine R. Giles Karthik Rajasekaran KC Wumesh Leonel Torres Maria A. Cardenas Mark M. Painter Matthew A. Sullivan Maura McLaughlin Max Klapholz Melody Tan Naomi R. Douek OncoDaily Oncology Rishi R. Goel Robert M. Brody Sasikanth Manne Shin Foong Ngiow Simone L. Park Simone Park Trenton Campos Victor Alcalde Victoria Fang Ying Liu Yinghui J. Huang