Oliver Maracic, Investor, shared an article by Leyi Huang, et al. on LinkedIn:
“Tumor-induced PNI can be observed in over 80% of patients with PDAC, significantly impacting their prognosis.
- Perineural invasion (PNI) is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC), which occurs at a high incidence and significantly contributes to PDAC lethality and poor survival.
- Combining small-molecule inhibitors targeting NAT10 and focal adhesion kinase (FAK) significantly attenuated PNI in vivo.
- N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma.”
N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma.
Authors: Leyi Huang, et al.
