Rachit Khandelwal

Rachit Khandelwal shares 2025 breakthrough update on Sinusoidal Obstruction Syndrome post-HSCT

Rachit Khandelwal, Pediatrics BMT fellow at Medanta The Medicity, shared a post on X about recent paper by Marion Larue published in Nature, adding:

“New 2025 update on Sinusoidal Obstruction Syndrome (SOS/VOD) post-HSCT

  • Liver is the main target
  • Early signs = sinusoidal congestion, hepatic ischemia
  • New 2023 EBMT criteria improve detection and stratification
  • Defibrotide remains gold standard for severe SOS
Early diagnosis = better outcomes.”

Management of liver sinusoidal obstruction syndrome/veno-occlusive disease in adults: a 2025 perspective from an international expert group

Authors: Marion Larue et al.

Rachit Khandelwal

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