Oscar Tahuahua, Medical Oncology Fellow at the National Cancer Institute of Mexico, shared a post on X about a recent paper by Nicholas J. Salgia et al. published in Cancer Cell:
“Genomic chaos (↑TMB, CDKN2A/B loss, TP53 muts, genomic instability) fuels an IFN γ-rich, PDL1 high, CD8+ rich TME.
ICIs lead to deep and durable responses in approximately 50–60% ”
Title: Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma
Journal: Cancer Cell
Authors: Nicholas J. Salgia, Adil Khan, Wilhelm M. Aubrecht, Gavin C. Twoey, Jacky Chow, Kristopher Attwood, Han Yu, Jessie L. Chiello, Nathaniel Hansen, Brianna J. Wasik, Benjamin D. Mercier, Hedyeh Ebrahimi, Luis Meza, Orla Maguire, Michalis Mastri, Cassandra Whalen, Hans Minderman, Patrick Pirrotte, Sara Byron, Elizabeth A. Repasky, Prashant K. Singh, Wiam Bshara, Jianmin Wang, A.J. Robert McGray, Scott I. Abrams, Bo Xu, Kevin H. Eng, Mark D. Long, Sumanta K. Pal, Eric C. Kauffman, Jason B. Muhitch
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