Michael Chuong, Vice Chair and Medical Director of the Department of Radiation Oncology at Miami Cancer Institute, shared a post on LinkedIn:

“Online adaptive radiotherapy (oART) is increasingly being used to deliver high ablative dose for inoperable pancreatic cancer that may improve patient survival.

However, the benefits of oART vs. standard non-adaptive RT have not previously been reported. Such data could be beneficial to guide treatment decisions, especially since oART is a technically complex and resource intensive procedure that is currently offered at a limited number of institutions.

This is the first in silico comparison of 5-fraction ablative pancreatic SBRT delivered w/ online adapted MR-guided vs. non-adapted CT-guided radiotherapy
120 total treatment plans were compared
Tumor coverage by an ablative dose was high in both cohorts
96% of all plans violated stomach/bowel constraints w/o oART
100% of all plans met stomach/bowel constraints w/ oART
These data support the importance of oART in enhancing safety when delivering ablative 5-fraction SBRT, which ideally should be delivered at a high-volume center.”

Title: Ablative Five-Fraction CT Versus MR-Guided Stereotactic Body Radiation Therapy for Pancreatic Cancer: In Silico Evaluation of Interfraction Anatomic Changes as a Rationale for Online Adaptive Replanning

Authors: Adeel Kaiser, Nicole Luther, Kathryn E. Mittauer, Amna Gul, Robert A. Herrera, Mukesh K. Roy, Ashley Fellows, Amy Rzepczynski, Will Deere, Matthew D. Hall, Rupesh Kotecha, Nema Bassiri-Gharb, Alonso N. Gutierrez, Michael D. Chuong

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Michael Chuong

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Michael Chuong: Ablative Five-Fraction CT Versus MR-Guided Stereotactic Body Radiation Therapy for Pancreatic Cancer

“Online adaptive radiotherapy (oART) is increasingly being used to deliver high ablative dose for inoperable pancreatic cancer that may improve patient survival.

However, the benefits of oART vs. standard non-adaptive RT have not previously been reported. Such data could be beneficial to guide treatment decisions, especially since oART is a technically complex and resource intensive procedure that is currently offered at a limited number of institutions.

This is the first in silico comparison of 5-fraction ablative pancreatic SBRT delivered w/ online adapted MR-guided vs. non-adapted CT-guided radiotherapy

120 total treatment plans were compared

Tumor coverage by an ablative dose was high in both cohorts

96% of all plans violated stomach/bowel constraints w/o oART

100% of all plans met stomach/bowel constraints w/ oART

These data support the importance of oART in enhancing safety when delivering ablative 5-fraction SBRT, which ideally should be delivered at a high-volume center.”