Mario Balsa, Medical Oncology Resident at Catalan Institute of Oncology (ICO), shared a post on X:
“New meta-analysis explores skipping 5-FU bolus in GI cancer chemo (7 studies | 12,698 pts).
No OS (HR 0.96) or PFS (HR 0.94) difference. Less toxicity without bolus:
- G3–4 neutropenia (OR 0.46)
- Thrombocytopenia (OR 0.53)
When it comes to 5-FU, less might just be more for the marrow. Congrats to Yakup Ergün and all the team.”
Title: Efficacy and safety of omitting 5-fluorouracil bolus in combination chemotherapy regimens for gastrointestinal cancers: a systematic review and meta-analysis
Authors: Yusuf Ilhan, Onur Yazdan Balcık, Elif Sahın, Aysegul Merc Cetınkaya, Elvina Almuradova, Murat Bardakcı, Cigdem Dınckal, Murat Karateke, Kadriye Bır Yucel, Arif Hakan Onder, Yakup Ergun
Read the Full Article.
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