Laura Bukavina, Urologic Oncologist at Cleveland Clinic, shared a post on X:
“New pub alert. The bladder microbiome may influence intravesical chemotherapy response in bladder cancer. We tested uropathogenic E. coli (UPEC) and gemcitabine
Results>
- Ecoli can enter tumor cells (of course)
- Inactivate gemcitabine → converting it to an inactive metabolite (dFdU)
- Reduce chemo’s ability to kill cancer cells.”
Title: Bladder cancer microbiome and its association with chemoresponse
Authors: Rashida Ginwala, Laura Bukavina, Mohit Sindhani, Erika Nachman, Suraj Peri, Jodie Franklin, John Drevik, Sarah Christianson, Daniel M. Geynisman, Alexander Kutikov, Philip H. Abbosh
Read the Full Article.
More posts featuring L. Bukavina.
