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Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Dana-Farber’s Breast Oncology Center shared a post on X:

“Check out the Breast Cancer Research Digest – a summary of last week’s publications from select high-impact journals (January 21st-26th, 2025).

HER2DX in HER2-positive inflammatory breast cancer: correlative insights and comparative analysis with noninflammatory breast cancers.

Authors: Lynce F, et al.

breast cancer

Efficacy, safety, and patient-reported outcomes across young to older age groups of patients with HR+/HER2- advanced breast cancer treated with ribociclib plus endocrine therapy in the randomized MONALEESA-2, -3, and -7 trials.

Authors: Lowell L Hart, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Molecular characterization of HER2-negative breast cancers reveals a distinct patient subgroup with 17q12 deletion and heterozygous loss of ERBB2.

Authors: Qiu X, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial.

Authors: Sherene Loi, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Pembrolizumab and chemotherapy in high-risk, early- stage, ER(+)/HER2(-) breast cancer: a randomized phase 3 trial.

Authors: Fatima Cardoso, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13]).

Authors: DeMichele A, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.

Authors: Fresia Pareja, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

The Role of Race/Ethnicity on the Association between Neighborhood Deprivation and Breast Cancer Outcomes among Kentucky Breast Cancer Patients years 2010-2022.

Authors: Breyanna Walker, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Obesity increases DNA damage in the breast epithelium.

Authors: Mohamed Gaber, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Bone-Induced Her2 Promotes Secondary Metastasis in HR+/Her2- Breast Cancer.

Authors: Rahat Alam, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Pretargeted Trop-2 immunoPET for rapid, selective detection of pancreatic tumors.

Authors: Edwin C Pratt, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Human Epidermal Growth Factor Receptor 2 Loss Following Treatment with Trastuzumab Deruxtecan in Patients with Metastatic Breast Cancer.

Authors: Mohamed A Gouda, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors.

Authors: Zhengyan Kan, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial.

Authors: Christian Kurzeder, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers.

Authors: Lothar Häberle et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Natural killer cells occupy unique spatial neighborhoods in HER2(-) and HER2(+) human breast cancers.

Authors: Femke A I Ehlers, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality.

Authors: Noor A M Bakker, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Long-Term Outcomes of Radiation Monotherapy Versus Combined Radiation Monotherapy + Hormone Therapy in Low-Risk Early-Stage Breast Cancer Patients 70 Years or Older After Breast-Conserving Surgery.

Authors: Astrid D Morris, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

Pertuzumab Retreatment for Human Epidermal Growth Factor Receptor 2-Positive Locally Advanced/Metastatic Breast Cancer (PRECIOUS Study): Final Overall Survival Analysis.

Authors: Yutaka Yamamoto, et al.

Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center

A C Dueck A DeMichele A Wolff A. Grinshpun A. Prat A. Vivancos A.D. Cherniack A.G. Waks Abigail Peoples Adam J. Katz Adam Wilson Adebola Adegboyega Aditya Bardia Adrian Lee Alberto Suárez Zaizar Alexander Bolaender Alexander Ring Amrit Gonugunta Ana Gvozdenovic Andrea Richardson Andreas Wicki Andrei Ungureanu Andrew Tutt Angela Kohler Anna Reva Anne Vincent-Salomon Aparna Chhibber Arnaud Quentel Astrid D Morris Aysegul A Sahin B. Overmoyer B. Walbaum B.E. Johnson Berta Sousa Bich Doan Nguyen-Sträuli Bora Lim Breast Cancer Bree M Lege Breyanna Walker Britta Weigelt C F Singer C. Bueno-Muiño C. Fesl C.M. Perou cancer Carlos Ignacio Rojas García Carolina Reduzzi Cassandra Lepetit Caterina Marchio Chaoting Liu Chonghui Cheng Chris Klaver Christian Kurzeder Christine Desmedt Christoph Rochlitz Christopher J. Lord Christopher J. Schwartz Cloé Dehours Courtney B Betts Cristina Saura Cvetka Grašič Kuhar D Czajkowska D Lake D. Cameron D. Hlauschek Dan Hasson Dana-Farber Breast Oncology Center Daniel Egle David Bauer David G Edwards David W. Cescon Debu Tripathy Delphine Loirat Denise A. Yardley Denise Vorburger Deniz Demircioglu Douglas A Hanes E Mayer E Shelley Hwang E Winer E. Sanfeliu E.A. Mittendorf E.P. Winer Ecaterina E. Dumbrava Edi Brogi Edwin C Pratt Elinita Pollard Elinor Sawyer Elisa Champanhet Elisabetta Molteni Elizabeth A. Mittendorf Emad Rakha Emily C Collins Eric B Durbin Ewald van Dyk F. Brasó-Maristany F. Lynce Fabienne D. Schwab Fabrice Andre Facundo Rufino Caminos Fatima Cardoso Felipe Ades Femke A I Ehlers Francesc Castro-Giner Fresia Pareja Fumikata Hara Funda Meric-Bernstam G G Steger G Kirkner G Rubovsky G Werutsky G. Pfeiler G. Villacampa Javierre Gábor Rubovszky Gabriela M. Kuster Gargi Damle Gary Sopher Gerard M J Bos Gilles Freyer Giuseppe Curigliano Grace Chao Gwenola Bougras-Cartron H Burstein H Gupta H Rugo H W Long H. Iwata Han Xiao Hana Triki Hannah Garner Hannah Linden Heather McArthur Heike Frauchiger-Heuer Hendrika M Oosterkamp Henry G Kaplan Hiroji Iwata Hiroshi Tada Hiroyuki Yasojima Hui Chen Huilin Hu Igor L Bado Iliana Tenvooren Ilona Krol Iris de Rink Iris Nederlof Isabell Witzel J Balko J.S. Parker Jadwiga Bienkowska Jason Mouabbi Jason S. Lewis Javier Cortés Jennifer Lapira-Miller Jennifer Webster Jenny Qun Wu Jerry E Chipuk Ji Wen Joaquin G. Reinoso-Toledo Jon Oyer Jordi Rodon Jorge S. Reis-Filho Jose Pablo Leone Joseph A. Sparano Joyce O'Shaughnessy Julia Holmes Julie E Lang Justin X Moore K A Parraga K Miller K P Theall Karin E. de Visser Katherine L. Cook Kathleen L. O'Connor Katie E Blise Kenji Tamura Kevin Kalinsky Kimberly Hyunjung Kim Koichiro Tsugawa Komal Mandleywala Konstantinos Tryfonidis L Scholl L.M. Anderson L.Paré Lajos Pusztai Laura M Natalee Laura S Munoz-Arcos Laura Spring Leonie Voorwerk Ling Wu Lisa M. Coussens Liyi Jia Lodewyk F.A. Wessels Loes F S Kooreman Lotte Wieten Lovoria B Williams Lowell L. Hart M Balic M Colleoni M Meyerson M. Bellet-Ezquerra M. Gnant M. Martín M.E. Hughes M.K. DiLullo Malini Harigopal Manuel Gonzalez Fernandez Manuel Nüesch Marcus Vetter Maren Vogel Margaret M Szabunio Mario Campone Marja Nieuwland Mark A Castanares Marleen Kok Marte C Liefaard Mary L. Duet Masahiro Kashiwaba Masakazu Toi Masato Takahashi Massimo Cristofanilli Maxime Duijst Melinda L. Telli Melissa Gao Misena Pacius Mohamed A. Gouda Mohamed Gaber N Wolmark N Zhou N. Zdenkowski N.U. Lin Nadia Harbeck Naoki Niikura Naoto T Ueno Naruto Taira Nicola Aceto Noor A. M. Bakker Norikazu Masuda O Metzger O. Martínez-Sáez OncoDaily Oncology Onno B. Bleijerveld P O'Brien P. Galván P. Tarantino P. Villagrasa Pamela C. Hull Paul A. Rejto Paula R. Pohlmann Pepper Schedin Peter A. Fasching Peter Schmid Pierre-Alexandre Vidi Pierre-François Cartron R D Lu R Jeselsohn. R Li Rahat Alam Raheel Nathani Rajalakshmi Chandra Rashmi Murthy Rina Hui Rita Canas Marques Roberto Iván Romero Díaz Roberto Salgado Rohit Bhargava Rosie Voorthuis S El-Abed S. Pernas S.M. Tolaney Samantha R Jones Sara M. Tolaney Sarina A Piha-Paul Satoshi Morita Selina Budinjas Senthil Damodaran Seock-Ah Im Shamilene Sivagnanam Sherene Loi Sherko Küemmel Shigehira Saji Shinji Ohno Simran Asawa Sofia D. Merajver Steffi Oesterreich Stuart J Schnitt Sunil R. Lakhani Suzette Delaloge Swarnima Singh Sydney P Howard T Traina Takashi Yamanaka Takayuki Ueno Tatsuya Toyama Tetsuhiro Yoshinami Thierry Pécot Thomas Decker Thomas Spires Timothy A Yap Timothy Pluard Todd VanArsdale Tomomi Fujisawa Toshimi Takano V Morgan Jones Valentina Guarneri Valerie Payne Vassiliki Karantza Vicente Valero Vinicius Bonato Viola Heinzelmann-Schwarz Virginia F. Borges Vladimir Ivanov Walter Paul Weber Wendi Ab Owen Wenjing Yang Whijae Roh X Qiu Xiang H-F Zhang Xiaoqin Wang Xiaoxin Hao Xinmeng Jasmine Mu Y Jiang Y. Hannah Wen Yeon Hee Park Yi-Hsuan Wu Yixian Wang Yoshie Hasegawa Yu Ding Yu Wei Zhang Yutaka Yamamoto Z Nowecki Zbigniew Gugala Zeru Tian Zhengyan Kan Zhenzhen Liu Zhimin Shao