Castalia Fernández, Radiation Oncology Specialist at GenesisCare, shared on X about a recent paper by Vinai Gondi et al. published on JCO:
“NRG-CC003 trial: Hippocampal avoidance (HA) during prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) didn’t meet primary endpoint for 6-month Hopkins Verbal Learning Test-Revised (HVLT-R) Delayed Recall preservation (30.0% vs 25.5% deterioration, p=0.28), but noninferior 12-month intracranial relapse (ICR; 14.8% vs 14.7%), reduced overall neurocognitive function (NCF) failure risk (hazard ratio/HR 0.78, p=0.039), no diff in overall survival (OS)/toxicity. Promising for neuroprotection! ”
Title: Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003
Authors: Vinai Gondi, Stephanie L. Pugh, Minesh P. Mehta, Jeffrey S. Wefel, Wolfgang A. Tomé, Alexander Y. Sun, John Grecula, Kristin J. Redmond, Shannon Fogh, Laurie Gaspar, Andre Konski, Joseph Bovi, Clifford G. Robinson, Benjamin Corn, Gregory M. Videtic, Benjamin H. Lok, Harold A. Yoon, John H. Heinzerling, Albert S. DeNittis, Ronald C. McGarry, Kiran Devisetty, Vijayananda Kundapur, Abraham J. Wu, Edward C. McCarron, Isabelle Thibault, Edmund L. Simon, Andrew M. Baschnagel, Samir Narayan, Jondavid Pollock, Rebecca Paulus, Lisa A. Kachnic
Giuseppe Minniti, Radiation Oncologist at Sapienza University of Rome, shared Castalia Fernández’s on X:
“Much more than just HA is necessary for preservation of neurocognition in patients receiving brain RT. Ongoing research is focusing on all limbic system, cingulate gyrus, precentral areas, and white matter tracts, among others.”
Other posts featuring Castalia Fernández.