Anirban Maitra, Scientific Director of the Pancreatic Cancer Research Center at MD Anderson Cancer Center, shared the following insight on X/Twitter:
“HUGE congratulations to Florencia McAllister, Vidhi Chandra and colleagues from MD Anderson Cancer Center for their Cancer Cell paper (cameo by Pylayeva-Gupta).
Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation.
This paper establishes the complex and compartment-specific roles (gut versus tumor microenvironment) of the IL17-IL17RA axis. IL17RA is required for maintaining gut microbiome homeostasis. Deletion of IL17RA in the gut leads to microbial dysbiosis and enhances homing of tumor-promoting Th17 cells and B cells to the tumor milieu, where IL-17 secretion promotes DUOX2-mediated tumor growth. This effect is seen in both Pancreatic Cancer and Brain Cancers, underscoring the importance of the gut microbiome homeostasis on distant tumor growth.”
Source: Anirban Maitra/X