CRISPR

Leveraging CRISPR to Uncover Plexin B2’s Role in Liver Metastasis

Authors:

CRISPR

“Scientific Wednesday Leveraging CRISPR to Uncover Plexin B2’s Role in Liver Metastasis: A Path to New Cancer Therapies.

A recent study published in Nature Portfolio provides important insights into metastasis. Using a novel in vivo CRISPR activation screen, researchers identified plexin B2 as a key regulator of liver colonization in cancer. This discovery highlights the role of liver-derived signals in metastatic seeding.

Key Takeaways:

  • Plexin B2’s interaction with tumor semaphorins promotes epithelial traits essential for metastasis.
  • Blocking plexin B2 can effectively prevent liver metastases, pointing to a promising therapeutic strategy.
  • The approach offers a framework for understanding metastasis in other organs.

This research not only deepens our understanding of cancer biology but also opens new avenues for metastasis prevention. A big step forward in the fight against cancer!

Find out more in the original source.”

“This research offers valuable insights into how liver-derived factors influence cancer metastasis, with plexin B2 identified as a crucial player.

Find out more about the potential to block this pathway and how it could revolutionize how we prevent cancer spread in the latest review by The Babak Lab. ”

Source:

Ab Meijs Andreas Moor Andromachi Karakatsani Ardian Mannhart Atefeh Lafzi cancer cancer metastasis Costanza Borrelli CRISPR Davide Eletto Elena Guido Vinzoni Farah Baccouche Mhamedi Hassan Fazilaty Ilhan Acar Jonas Kretz Kristina Handler Maria Babak Marie-Didiée Hussherr Morgan Roberts Nature Nature Portfolio OncoDaily Oncology Plexin B2 Randall Platt Research Salvatore Piscuoglio Scientific Wednesday Shoichiro Kimura Srivathsan Adivarahan Tomas Valenta Xenia Ficht