The National Cancer Institute (NCI) and National Institute on Aging (NIA) invite applications to establish or improve cancer models that integrate age-related biological changes. These “oncoaging” models should recapitulate how aging influences tumor initiation, progression, and treatment response, enabling mechanistic and translational studies relevant to older adults with cancer.
Eligibility Criteria:
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Any U.S. or foreign higher education institution, nonprofit research organization, or for-profit entity eligible to submit under the chosen parent FOA (e.g., R01, R21).
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Principal Investigator must possess appropriate credentials and experience in cancer biology, aging research, or allied fields.
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Proposed project must address one or more aims listed in the NOSI, such as developing or validating preclinical oncoaging models or elucidating mechanistic links between aging hallmarks and tumor biology.
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Applicants cannot submit applications that ignore the biological context of aging or focus solely on cancer risk/prevention without modeling age-related changes.
Funding Details:
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Mechanisms: Submit under one of the following parent FOAs (or their reissues) through July 31, 2027:
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PA-20-185 (R01 Clinical Trial Not Allowed)
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PA-20-195 (R21 Clinical Trial Not Allowed)
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PAR-22-216 (R21 Clinical Trial Optional)
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PAR-22-099 (R01 Clinical Trial Optional)
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PAR-23-281 (R01 Clinical Trial Not Allowed)
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Budget & Duration: Follow the parent announcement’s instructions for budget caps and project periods (typically up to 5 years for R01; up to 2 years for R21).
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Inclusion of “NOT-CA-23-092”: Must enter “NOT-CA-23-092” in Agency Routing Identifier box 4B of the SF424 (R&R) form to ensure consideration under this NOSI.
Deadline:
All parent FOA due dates through July 31, 2027 (expiration date).
Where to Go for Further Information:
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Contact NCI Scientific Inquiry:
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Margaret Klauzinska, Ph.D. ([email protected])
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Weiwei Chen, Ph.D. ([email protected])
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Contact NIA Scientific Inquiry:
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Max Guo, Ph.D. ([email protected])
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