Steven Artandi, Director of the Stanford Cancer Institute, shared the following on X:
“Stanford Cancer Institute members Howard Y. Chang, Paul Mischel, and others found support for a model of ecDNA formation in which double-strand break ends dissociate from their legitimate ligation partners prior to joining of illegitimate ends to form the ecDNA and excision scar.”
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair
Authors: John C. Rose, Julia A. Belk, Ivy Tsz-Lo Wong, Jens Luebeck, Hudson T. Horn, Bence Daniel, Matthew G. Jones, Kathryn E. Yost, King L. Hung, Kevin S. Kolahi, Ellis J. Curtis, Calvin J. Kuo, Vineet Bafna, Paul S. Mischel, Howard Y. Chang
