Sergio Cifuentes Canaval, Cancer Research Project Manager at CENEIT Mexico, posted on LinkedIn:
“Predictors of Response to CDK4/6i Rechallenge in ER+ Metastatic Breast Cancer
This retrospective study, despite its limitations, addresses an often-posed question in clinical practice that remains unresolved by randomized trials. Changing CDK4/6i after progression on initial treatment is a common strategy, driven by both the trust in the first-line CDK4/6i approach and the limited efficacy or availability of subsequent options. This analysis offers reassurance regarding this practice and highlights the potential utility of molecular profiling for better decision-making.”