Brian Rini

Marcin Kortylewski: Multimodal Glioma Immunotherapy Targeting STAT3 and PD-1

Marcin Kortylewski, Professor at City of Hope, posted on LinkedIn:

“Just published! Our latest study on a new STAT3-targeting and double-stranded antisense oligonucleotide (CpG-STAT3dsASO) that reprograms the glioblastoma microenvironment and restores sensitivity to PD1 blockade. The oligo design was optimized for safety and led to long-term survival in preclinical GBM models.

Grateful to our expert collaborators including Amy Heimberger and Bozena Kaminska for their invaluable contributions to this work.”

“Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade.”

Authors: Chia-Yang Hung, Elaine Y Kang, Karol Jacek, Chunsong Yu, Xiaowei Zhang, Yicheng Zhu, Maryam Aftabizadeh, Robyn A Wong, Benham Badie, Piotr Swiderski, Bożena Kaminska, Darya Alizadeh, Amy B Heimberger, Christine Brown, Marcin Kortylewski

Marcin Kortylewski: Multimodal Glioma Immunotherapy Targeting STAT3 and PD-1

 

Amy B Heimberger Amy Heimberger Benham Badie Bozena Kaminska cancer Chia-Yang Hung Christine Brown Chunsong Yu Darya Alizadeh Elaine Y Kang glioblastoma immunotherapy Karol Jacek Marcin Kortylewski Maryam Aftabizadeh OncoDaily Oncology Piotr Swiderski Robyn A Wong Xiaowei Zhang Yicheng Zhu