Katsuaki Maehara: CXCL13-Reprogrammed Macrophages Drive Cancer-Associated Pulmonary Embolism

Katsuaki Maehara, Director of Medical Education Colleagues, posted on X:

“Pulmonary embolism.

Pulmonary embolism is a frequent and important complication of cancer, and this paper reveals the molecular mechanism by which pulmonary interstitial macrophages, reprogrammed by CXCL13, secrete vesicles that induce thrombi.”

“Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.”

Authors: Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Jacob Geri, Young Hun Kim, Jinghua Gu, Uthra Balaji, Linda Bojmar, Lee Shaashua, Yi Song, Michele Cioffi, Pernille Lauritzen, Oveen M. Joseph, Tetsuhiko Asao, Paul M. Grandgenett, Michael A. Hollingsworth, Christopher Peralta, Alexandra E. Pagano, Henrik Molina, Harry B. Lengel, Elizabeth G. Dunne, Xiaohong Jing, Madeleine Schmitter, Lucia Borriello, Thomas Miller, Haiying Zhang, Yevgeniy Romin, Katia Manova, Doru Paul, H. Lawrence Remmel, Eileen M. O’Reilly, William R. Jarnagin, David Kelsen, Sharon M. Castellino, Lisa Giulino-Roth, David R. Jones, John S. Condeelis, Virginia Pascual, James B. Bussel, Nancy Boudreau, Irina Matei, David Entenberg, Jacqueline F. Bromberg, Diane M. Simeone, David Lyden