Gaia Griguolo: TOP1 Mutations are more frequent after treatment with ADCs

Gaia Griguolo: TOP1 Mutations are more frequent after treatment with ADCs

Gaia Griguolo ,Medical Oncologist at the Department of Medical Oncology, Veneto Institute Oncology (IRCCS), shared a post on X:

“TOP1 Mutations are more frequent after treatment with ADCs and might be linked to resistance to SN38 and deruxtecan -potential mechanism for crossresistance?”

TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer

Authors: Rachel O. Abelman et al.

Gaia Griguolo

Aditya Bardia Andreas Varkaris Annika Putur Arielle Medford Beverly Moy Bogang Wu Bryanna Norden cancer Caroline Weipert Dejan Juric Elena Bitman Gaia Griguolo Geoffrey Fell Haley Barnes Laura M. Spring Leif W. Ellisen Neelima Vidula OncoDaily Oncology Rachel O. Abelman Ryan Corcoran Seth Wander Steven J. Isakoff Ting Liu Win Thant