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Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Dana-Farber Lank Center for Genitourinary Oncology shared a post on X:

“GU Research Digest for the week of February 8 – 14: a selection of publications about GU cancers in high-impact journals. Search the PMIDs on http://pubmed.ncbi.nlm.nih.gov to read!”

Genitourinary/Immunotherapy/General

Renal

Efficacy and safety of nivolumab plus ipilimumab in patients with metastatic variant histology_(non-clear cell) renal cell carcinoma.

Authors: Mohammad Jad Moussa et al. 

dana-farber

Cancer and Overgrowth Manifestations of PTEN Hamartoma Tumour Syndrome: Management Recommendations from the International PHTS Consensus Guidelines Working Group.

Authors: Andrew Dhawan et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma. 

Authors: Chengheng Liao, et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Bladder/Urothelial

Safety and efficacy of neoadjuvant durvalumab plus gemcitabine/cisplatin or carboplatin in patients with operable high-risk upper tract urothelial carcinoma: the iNDUCT trial. 

Authors: Nadine Houédé et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Sacituzumab govitecan in advanced urothelial carcinoma: TROPICS- 04, a phase III randomized trial. 

Authors: Thomas Powles et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial. 

Authors: Aung Naing et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Prostate

Overall survival and quality of life with [177Lu]Lu-PSMA-617 plus enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer (ENZA-p): secondary outcomes from a multicentre, open-label, randomised, phase 2 trial. 

Authors: Louise Emmett L, et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer.

Authors: Rachel R Xiang, et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Combination Therapies in Locally Advanced and Metastatic Hormone- sensitive Prostate Cancer.

Authors: Arun A. Azad et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

The Germline and Somatic Origins of Prostate Cancer Heterogeneity. 

Authors: Takafumi N Yamaguchi et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Effective Treatment of Disseminated Prostate Cancer Using CD46- Targeted 225Ac Therapy. 

Authors: Anil P Bidkar et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients. 

Authors: Daniel Magee et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry_groups. 

Authors: Thomas J. Hoffmann et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Targeting ADAR1 with a small molecule for the treatment of prostate cancer. 

Authors: Xiao Wang et al.

Dana-Farber Lank Center for Genitourinary Oncology Research Digest

Adam Oskowitz Adanma Ayanambakkam Adriana Salcedo Adrien Foucal Ailsa Langford Akindele O. Adebiyi Alain Bergeron Alain Ruffion Alex A. Rodriguez Alexander Gusev Alexandra Masson-Lecomte Alicia McCarther Alison Yan Zhang Amar U. Kishan Amishi Shah Amy C. Justice Andrew C Johns Andrew D Redfern Andrew Dhawan Andrew James Martin Andrew Lonie Andrew Nguyen Andrew Ryan Andrew Weickhardt Anil P Bidkar Anja Victor Anju Wadhwa Anne Nguyen Anqi Wang Anthony F Shields Anthony J Costello Anthony M Joshua Anthony T Papenfuss Anthony Tolcher Anusha R Bhatia Aravind S. Ravi Kumar Arun A. Azad Athira Raveendran Aung Naing Ben Adusei Benjamin J Hauk Bernard J Pope Bernard Têtu Bertrand Tombal Bin Liu Bogdan Pasaniuc Bradley Somer Brandon L. Pierce Brian Shimkus Brigitte Laguerre Burcu F. Darst cancer Caroline Andrews Caroline F Tyndall Cassandra Singler Cathee Till Chandrashekhar Dasari Charis Eng Cheng Zhang Chengheng Liao Chengliang Sun Chol-Hee Jung Chris Parker Christine Abraham Christopher A. Haiman Christopher J. Sweeney Christopher M Hovens Christopher M Lalansingh Clinton L. Cario Connor Bell Constance Thibault Craig Gedye Damien Pouessel Daniel Holland Daniel J Park Daniel Magee Daniel Patterson Darren Liu David A Pattison David Hsiehchen David M Wilson David P Nadebaum David Pook David Spetzler David V. Conti David Y Takeda Devaki Shilpa Surasi Dilrini K. Ranatunga Dorota Hs Sendorek Edward O'Connor Elisabeth Heath Elshad Hasanov Emilia Richter Eric Jonasch Eva K F Chan Evanguelos Xylinas Fangzhou Zhao Fei Huang François Audenet Geoff Schembri George W. Sledge Geraldine Pignot Gerhardt Attard Guillaume Luquiens Gwenaelle Gravis Haiping Hao Hans Lilja Hao Shen Hayley Thomas Helen Ajufo Helen Zhu Hélène Gauthier Hélène Hovington Henry F VanBrocklin Hongtao Shen Hongwei Yao Hongyi Liu Housheng H He Hua Zhong Ian D Kirkwood Ian D. Davis Ian Pinto Ian Thompson Ilir Agalliu Jaanki Khandelwal Jagathi Challagalla James Brugarolas James E. Mensah Jeff Swensen Jeffrey C. Goh Jennifer Cultrera Jennifer R Ribeiro Jeremy M. Simon Ji-Heui Seo Jiang He Jiapei Yuan Jiaxing Li Jiayu Ding Jim Abraham Jin Zhou Jirong Long Joachim Weischenfeldt Joanne Ngeow Job van Riet Jocelyn Sietsma Penington John D McPherson John P. Shelley John S. Witte Jonathan Chou Jonathan D. Mosley Joseph Lachance Joseph Presti Juan Antonio Camara Serrano JuanJuan Yin Jue Jiang Julie Livingstone Jun Fang Jüri Reimand Justin S Peters Kai Yuan Kangsan Kim Kanishka Sircar Karen Feng Karim Bensalah Karim Fizazi Kathleen E Houlahan Ken Chow Kerry Schaffer Keyvan Tadjalli-Mehr Khaled M Elsayes Kiran L Malikayil Kodi Taraszka Kondapa Naidu Bobba Kristin Anthony Lachlan McIntosh Lamis Yehia Laurence Krieger Lawrence E Heisler Lei Dong Lei Guo Lei Huang Lianxin Hu Lillian L. Siu Lin Tong Lin Xu Linda Kachuri Liping Wang Lisa Horvath Liwei Jia Loïc Jaffrelot Louis Lacombe Louisa B. Goss Louise Emmett Louise Kostos Lydia Y. Liu Magdalena Jurkiewicz Marc Tischkowitz Marco A F Nogueira Filho Marek Cmero Margaret McJannett Mark M Pomerantz Mark Voskoboynik Martijn P Lolkema Martin R. Stockler Mathieu Roumiguié Matthew L. Freedman Matthew Oberley Matthew P Kipp Matthew R. Smith Matthew T Campbell Matthew Wakefield Megan Crumbaker Megan Landsverk Megha Basak Meredith McKean Michael Fraser Michael J Clarkson Michael Kerger Michael S Hofman Michel Velez Michèle Orain Milan Radovich Minghui Ji Mitchell J. Machiela Mohamed Jalloh Mohammad Jad Moussa Morgan Roupret Nadine Houédé Nancy Greenland Natalie K Rutherford Natalie Kurganovs Natalie S Fox Nathaniel R. Wilson Neal D. Freedman Neeraj Agarwal Niall M Corcoran Nicoline Hoogerbrugge Nieves Perdigones Borderias Niranjan Meher Nizar M. Tannir Noah Zaitlen Omar Alhalabi OncoDaily Oncology Oseremen I. Aisuodionoe-Shadrach Patricia Bastick Patrick Butler Patrick J McCoy Paul C. Boutros Pavlos Msaouel Payal Kapur Pedro W. Fernandez Peng Yang Peter Georgeson Peter Lin Pheroze Tamboli Phillip D Stricker Phyllis J. Goodman Ping Hu Praveena Solipuram Priya Rao Qian Liang Qing Zhang Rachel R Xiang Rahul Aggarwal Raja Mehdi Ralph J. DeBerardinis Ram S Mani Ravi K. Madduri Rayjean J Hung Rebecca E. Graff Renuka Sriram Riana M S Bornman Richard Jovelin Robert G Bristow Robert Hahn-Lowry Robert J. Klein Robert Lesurf Robert R. Flavell Robin Peter Rohini Janivara Roslyn J Francis Ryan Stuchbery Sangeeta Goswami Sarah Baitamouni Scott Bidlingmaier Scott Eggener Scott Kogan Sebastian M Waszak Shadrielle Melijah G Espiritu Shahneen Sandhu Shakher Ramdave Shalini Subramaniam Shengchao A. Li Shin-Ai Lee Shina Li Shingai B.A. Mutambirwa Shubhankar Naik Shun-Qing Liang Silke Gillessen Siobhan Ng Sonja I. Berndt Sophie Tartas Srinivas Malladi Stefano Mangiola Stephan Gleicher Stéphane Droupy Stephen J. Chanock Stephen K. Van Den Eeden Stephenie D Prokopec Supriya Koya Susmita G Ramanand Suzanne P. MacFarland Sze Ting Lee Takafumi N. Yamaguchi Tanya Dorff Tao Wang Tharakeswara K. Bathala Thean Hsiang Tan Theodorus van der Kwast Thierry Chevallier Thomas J. Hoffmann Thomas Kitzing Timothy Rebbeck Ting Zeng Tommer Schwarz Valérie Picard Valeriy Domenyuk Vanessa M Hayes Veronica Sabelnykova Veronica Steri Vinayak Bhandari Vincent Huang Weerachai Jaratlerdsiri Wei Chua Wei Gao Weijiao Chen Wen-Yi Huang Wenbin Kuang Wenjian Min Wenlong C. Chen William Blot William Macdonald Xiao Wang Yann Neuzillet Yasheng Zhu Yi Hou Yibei Xiao Yiyun Lin Youngho Seo Yu Jiang Yu-Jia Shiah Yuzhang Jiang Yves Fradet Zhongrui Shi