Our results reveal a physiologic function of Mdm2 in BM-MSC, identify a previously unknown role of p53 pathway in BM-MSC–mediated support in AML

In a post by Jared K. Burks on Linkedin, it says, “This is a double celebration as not only did I get to contribute to this wonderful article, but the first author, Russell Pourebrahim was just promoted to Assistant Professor. Congrats Rasoul on both the article and the promotion, very happy for you.
Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for the maintenance of hematopoietic stem cells. To advance our understanding of physiological functions of p53 and Mdm2 in BM-MSCs, we developed traceable conditional mouse models targeting Mdm2 and/or Trp53 in vivo. Our results reveal a physiologic function of Mdm2 in BM-MSC, identify a previously unknown role of p53 pathway in BM-MSC–mediated support in AML and expand our understanding of the mechanism of hematopoietic toxicity of MDM2is.”

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Source: Jared K. Burks/Linkedin